Background. Necrotizing fastsyyt rapidly progressing, life-threatening infection that primarily involves the soft tissues. Traditionally, group A streptococcus is a major cause of the disease. In recent years, however, an increasing number of reported cases of necrotizing fastsyyt exclusively caused by Klebsiella pneumonia. There are limited data on clinical and microbiological features of K. pneumonia strains causing the disease. The methods. We plan to review medical records necrotic fastsyyt treated during 1996-2009 to the National Taiwan University Hospital, and compare the clinical features of cases caused by pneumonia and K cases caused by streptococcus strattera dosage group A. We also plan to retrospectively identify necrotic fastsyyt related K. pneumonia strains stored at 80 ° C, the National Taiwan University Hospital, and perform virulence phenotyping related hypermucoviscosity, wzy (Mage locus), rmpA genotyping, and 20 kb Kraft / CTV genome. Expected results. This study is expected to provide the following important information: (1) the prevalence of monomicrobial necrotizing pneumonia K. fastsyyt cases among all cases of necrotizing fastsyyt in our clinic during the study period (2) different clinical signs of pneumonia K. necrotizing fastsyyt using the group A streptococcus necrotizing fastsyyt as in the comparison group (3) microbiological characteristics of K. pneumonia strains causing monomicrobial necrotizing fastsyyt, including hypermucoviscosity phenotype, wzy (Mage locus) and rmpA genotype. .
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